Endothelial Lineage Differentiation from Induced Pluripotent Stem Cells Is Regulated by MicroRNA-21 and Transforming
نویسندگان
چکیده
Background: Induced pluripotent stem cells (iPSCs) constitute an attractive source of cells for regenerative medicine. Results:MicroRNA-21 mediates endothelial differentiation derived from iPSCs in presence of VEGF. Conclusion:MicroRNA-21 and TGF2 signaling pathways regulate iPSC differentiation to endothelial lineage. Significance:Elucidation of themolecularmechanisms underlyingmicroRNA-21-regulated iPSCdifferentiationmight provide the basic information for stem cell therapy of vascular diseases.
منابع مشابه
Endothelial Lineage Differentiation from Induced Pluripotent Stem Cells Is Regulated by MicroRNA-21 and Transforming Growth Factor β2 (TGF-β2) Pathways*
Finding a suitable cell source for endothelial cells (ECs) for cardiovascular regeneration is a challenging issue for regenerative medicine. In this paper, we describe a novel mechanism regulating induced pluripotent stem cells (iPSC) differentiation into ECs, with a particular focus on miRNAs and their targets. We first established a protocol using collagen IV and VEGF to drive the functional ...
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